发给老马备查:
5 ]- ~3 ^. K, p7 b( Z滴水察海(69304838) 15:23:23
4 m) |! K7 v8 o, L& T7 Q老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱! @: s8 C5 D0 K. j( u R9 Z
吉非替尼和S-1连用的依据, v# D( R S% [! |
Gefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.& l: l4 s( K! o7 z+ U# }
是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达6 Y+ D0 a8 Y( I( D, ?/ e
这样是不是推理出,耐药后,可以用S-1和培美了?* ?' Z( ?+ E! ] w; }" V7 G9 R& p
结论:: `9 i' @ R; ~8 w3 F' k8 I
如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |