发给老马备查:
r3 D+ t8 ]0 r滴水察海(69304838) 15:23:23
0 H# T' s2 z/ m* M! I老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱/ r+ m6 b# b9 d1 V
吉非替尼和S-1连用的依据# g* Z: @( t( d$ ]" [
Gefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.# s* F* j# N' J- r- n
是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达
& i* ~& j# l# u/ Z9 a: B这样是不是推理出,耐药后,可以用S-1和培美了?) F, Y# o' y; R2 X4 E! |7 o8 J, W1 [+ I
结论: [& ?1 Y( q8 ]' E" t
如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |